BPC-157 10mg

BPC-157 (GEPPPGKPADDAGLV) is a 15-amino-acid synthetic peptide investigated in preclinical models for effects on cellular proliferation, migration, and inflammatory signaling. The peptide’s mechanism involves multiple intracellular signaling cascades in cultured cell systems with established dose-response relationships and reproducibility.

BPC-157 Preclinical Mechanism & Research Context

Preclinical studies demonstrate BPC-157 activation of growth factor signaling pathways, including upregulation of VEGF and FGF expression in cultured fibroblasts and endothelial cells. The peptide exhibits anti-inflammatory effects in lipopolysaccharide-stimulated macrophage cultures and enhances epithelial cell migration in wound healing assays. Mechanistic studies suggest involvement of Ras/MAPK, PI3K, and eNOS-dependent pathways with measurable phosphorylation of downstream substrates.

BPC-157 Peer-Reviewed Preclinical Research

PLOS ONE (2014) characterized BPC-157 signaling in multiple cell types using phosphoproteomics and gene expression analysis. Molecules (2020) reviewed cumulative preclinical evidence across wound healing, inflammation, and tissue regeneration models. Frontiers in Pharmacology (2021) evaluated the peptide’s effects on angiogenesis in 3D tissue constructs and multi-cellular interactions.

BPC-157 Cell Culture & Tissue Applications

Standard use in fibroblast proliferation assays, epithelial wound healing models, endothelial tube formation protocols, and macrophage inflammatory response studies. Typical working concentration: 10-100 nM with consistent reproducibility across experimental replicates and batches.

BPC-157 10mg Product Specifications

10mg lyophilized peptide. Store -20°C, sealed and desiccated. Purity ≥98% by HPLC. Reconstitution in sterile saline/PBS (1-10 mg/mL). Minimum 24-month stability at proper storage temperature.

BPC-157 Research Use Only Disclaimer

This product is intended exclusively for in vitro preclinical research. Not approved for human use, clinical application, or in vivo animal testing. Researcher must comply with institutional biosafety and chemical handling guidelines.