MOTS-C

Buy MOTS-C 10mg for Research Online

MOTS-C (Mitochondrial-Derived Peptide) represents a 16-amino acid signaling molecule identified in mitochondrial matrix fractions, selected for investigation of mitochondrial-to-nuclear communication and cellular stress response pathways. This endogenous peptide operates as a secreted signaling factor distinct from nuclear-encoded proteins.

MOTS-C Mechanism of Action

The peptide sequence incorporates functional domains enabling interaction with formyl peptide receptors (FPR1 and FPR2) expressed on immune cell surfaces and alternative signaling targets currently under investigation. MOTS-C represents one of several mitochondrial-derived peptides characterized through proteomic approaches examining mitochondrial proteomes.

Cellular research employs MOTS-C to examine metabolic resilience in glucose deprivation models, nutrient stress conditions, and mitochondrial dysfunction paradigms. Insulin sensitivity measurements in myotube and hepatocyte preparations demonstrate MOTS-C effects on glucose uptake and utilization through metabolic labeling assays.

In vivo metabolic studies in rodents employ MOTS-C administration to examine fasting glucose, insulin resistance, and body weight parameters. Glucose tolerance testing with intraperitoneal glucose challenge quantifies MOTS-C effects on systemic glucose homeostasis.

Immune cell signaling investigations examine MOTS-C engagement with FPR receptors using transfected cell systems and primary immune cell preparations, measuring downstream calcium mobilization and chemotaxis responses through fluorometric and transmigration assays.

MOTS-C 10mg Product Specifications & Storage

Our MOTS-C 10mg formulation provides lyophilized powder at >95% purity verified through HPLC and mass spectrometry. Identity confirmation through peptide sequencing ensures sequence fidelity.

Reconstitute in sterile PBS or water for cellular and in vivo applications; store powder at -20°C for extended stability (24+ months). Reconstituted solutions maintain activity at 4°C for 10-14 days under aseptic conditions.

MOTS-C is supplied exclusively for research investigations in academic and commercial laboratory settings. This compound is not approved for human administration, therapeutic use, or veterinary application. All protocols must comply with institutional biosafety and animal care guidelines.